Author

L. A. St Clair

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

R. Perera· 4 shared J. M. Burke· 2 shared R. Parker· 2 shared A. Nag· 1 shared C. Montgomery· 1 shared E. Lian· 1 shared E. R. Worden-Sapper· 1 shared G. Ramirez· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersMicrobiology

R. Perera

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Human sialidase activity is vital for dengue virus serotype 2 infection

L. A. St Clair, P. G. Pujari, R. Perera

This study shows that sialidase activity is essential for dengue virus serotype 2 replication and egress, and that NEU1-3 depend transcriptionally on NEU4.

bioRxiv · Oct 5, 2022 · PreprintMicrobiology

RNase L-mediated RNA decay alters 3' end formation and splicing of host mRNAs

J. M. Burke, N. Ripin, M. B. Ferretti, L. A. St Clair, E. R. Worden-Sapper, S. L. Sawyer, R. Perera, K. W. Lynch, R. Parker

This study shows that RNase L-mediated RNA decay causes RNA-binding proteins to shift from cytoplasm to nucleus, altering splicing and 3' end formation of host mRNAs, especially interferons.

bioRxiv · Jan 28, 2022 · PreprintImmunology

Acyl-CoA Thioesterases; a rheostat that controls activated fatty acids modulates dengue virus serotype 2 replication

L. A. St Clair, S. A. Mills, E. Lian, P. S. Soma, A. Nag, C. Montgomery, G. Ramirez, N. Chotiwan, R. C. Gullberg, R. Perera

This study investigates the role of acyl-CoA thioesterases (ACOTs) in modulating dengue virus serotype 2 replication, showing that their loss of function affects viral replication and infectious particle release.

bioRxiv · Dec 12, 2021Microbiology

Rapid decay of host basal mRNAs during SARS-CoV-2 infection perturbs host antiviral mRNA biogenesis and export

J. M. Burke, L. A. St Clair, R. Perera, R. Parker

This study shows SARS-CoV-2 infection inhibits IFN mRNA biogenesis and export by blocking nuclear-cytoplasmic transport and triggering mRNA degradation.

bioRxiv · Apr 19, 2021 · PreprintImmunology