Author

S. L. Sawyer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. M. Burke· 2 shared R. Parker· 2 shared A. Barbachano-Guerrero· 1 shared A. R. Gilchrist· 1 shared A. Stabell· 1 shared C. Warren· 1 shared E. R. Worden-Sapper· 1 shared K. Patterson· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

J. M. Burke

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Adaptation of CD4 in gorillas and chimpanzees conveyed resistance to simian immunodeficiency viruses

C. Warren, A. Barbachano-Guerrero, V. DuMont, A. Stabell, O. Dirasantha, Q. Yang, S. L. Sawyer

The paper investigates how CD4 receptor variants in gorillas and chimpanzees confer resistance to SIVs, showing that selective pressure shaped these variants to block viral entry.

bioRxiv · Nov 13, 2023Microbiology

RNase L-mediated RNA decay alters 3' end formation and splicing of host mRNAs

J. M. Burke, N. Ripin, M. B. Ferretti, L. A. St Clair, E. R. Worden-Sapper, S. L. Sawyer, R. Perera, K. W. Lynch, R. Parker

This study shows that RNase L-mediated RNA decay causes RNA-binding proteins to shift from cytoplasm to nucleus, altering splicing and 3' end formation of host mRNAs, especially interferons.

bioRxiv · Jan 28, 2022 · PreprintImmunology

RNase L limits host and viral protein synthesis via inhibition of mRNA export

J. M. Burke, A. R. Gilchrist, S. L. Sawyer, R. Parker

The paper shows RNase L inhibits viral protein synthesis by blocking mRNA export rather than degrading viral mRNA, and regulates antiviral cytokine production.

bioRxiv · Apr 18, 2021Immunology

Control of Genetic Parasites Mediated Through Nucleoporin Evolution

P. A. Rowley, K. Patterson, S. B. Sandmeyer, S. L. Sawyer

The paper shows that natural selection on nucleoporin genes in yeast affects retrotransposon control without compromising essential nuclear pore functions.

bioRxiv · Nov 7, 2017Evolutionary Biology