Author

K. J. Waldron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:bacteria (other)· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1

Frequent Co-Authors

C. L. Mackay· 3 shared C. Piergentili· 3 shared D. J. Clarke· 3 shared J. Marles-Wright· 3 shared J. Ross· 3 shared D. He· 2 shared E. S. Mackenzie· 2 shared K. J. Gallagher· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersBiochemistry

C. L. Mackay

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes.

Y. Hong, E. S. Mackenzie, S. J. Firth, J. F. Bolton, L. J. Stewart, K. J. Waldron, K. Y. Djoko

This study shows that Cu stress in GAS leads to mis-regulation of Zn and Mn homeostasis, affecting growth and lactate secretion, without altering cellular Cu levels.

bioRxiv · Sep 28, 2022 · PreprintMicrobiology

Mircubactin B rescues the lethal effect of cell wall biosynthesis mutations in Bacillus subtilis.

B. Kepplinger, X. Wen, A. R. Tyler, B.-Y. Kim, J. Brown, P. Banks, Y. Dashti, E. S. Mackenzie, C. Wills, Y. Kawai, K. J. Waldron, N. E. E. Allenby, L. J. Wu, M. J. Hall, J. Errington

The paper identifies mirubactin B, a compound that rescues growth defects in Bacillus subtilis rod-complex mutants, showing activity beyond simple iron sequestration.

bioRxiv · Apr 24, 2022 · PreprintMicrobiology

Pore dynamics and asymmetric cargo loading in an encapsulin nanocompartment

J. Ross, Z. McIver, T. Lambert, C. Piergentili, K. J. Gallagher, J. E. Bird, F. L. Cruickshank, P. James, E. Zarazua-Arvizu, L. E. Horsfall, K. J. Waldron, M. D. Wilson, C. L. Mackay, A. Basle, D. J. Clarke, J. Marles-Wright

The paper uses cryo-EM and HDX-MS to analyze an encapsulin nanocompartment, revealing asymmetric cargo loading and dynamic pore behavior.

bioRxiv · Apr 15, 2021Biochemistry

A role for glutathione in buffering excess intracellular copper in Streptococcus pyogenes

L. J. Stewart, C.-l. Y. Ong, M. M. Zhang, S. Brouwer, L. McIntyre, M. R. Davies, M. J. Walker, A. G. McEwan, K. J. Waldron, K. Y. Djoko

This study shows that glutathione buffers excess intracellular copper in Streptococcus pyogenes when the Cu export system is overwhelmed, allowing bacterial survival despite copper toxicity.

mBio · Dec 22, 2020Peer-reviewedMicrobiology

Dissecting the structural and functional roles of a vicinal iron-binding site in encapsulated ferritins

C. Piergentili, J. Ross, D. He, K. J. Gallagher, W. A. Stanley, L. Adam, C. L. Mackay, K. J. Waldron, D. J. Clarke, J. Marles-Wright

This study investigates the structural and functional role of a secondary iron-binding site in encapsulated ferritins using enzymatic assays, mass-spectrometry, and X-ray crystallography.

bioRxiv · Apr 28, 2020 · PreprintBiochemistry

Conservation of the structural and functional architecture of encapsulated ferritins in bacteria and archaea

D. He, C. Piergentili, J. Ross, E. Tarrant, L. R. Tuck, C. L. Mackay, Z. McIver, K. J. Waldron, D. J. Clarke, J. Marles-Wright

The paper structurally and functionally characterizes two EncFtn proteins from different species, showing conserved structure and catalytic activity despite diverse environments.

bioRxiv · Sep 30, 2018Biochemistry