Author

L. Almassalha

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Approach:microscopy & imaging analysis· 2 Research Focus:cell signaling & trafficking· 1 Assay:Hi-C· 1

Frequent Co-Authors

V. Backman· 3 shared E. M. Pujadas· 2 shared A. A. McCarthy· 1 shared A. D. Stephens· 1 shared A. Daneshkhah· 1 shared A. Eshein· 1 shared A. Janssen· 1 shared A. Kuklinski· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

V. Backman

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Author profile →

3 papers

Recent·Most cited

DNA density is a better indicator of a nuclear bleb than lamin B loss

S. Bunner, K. Prince, K. Srikrishna, E. M. Pujadas, P. Pellegrino, J. Aiello, A. A. McCarthy, C. Lawlor, S. Jagtap, A. Kuklinski, G. Yas, N. LaPointe, I. Eweka, E. Eastin, O. Jackson, , A. D. Stephens

The paper compares lamin B and DNA levels in nuclear blebs across cell types and perturbations, finding DNA concentration is more consistently reduced than lamin B levels.

bioRxiv · Feb 6, 2024 · PreprintCell Biology

Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism

E. M. Pujadas, X. Wei, N. Acosta, L. Carter, J. Yang, L. Almassalha, A. Daneshkhah, S. S. P. Rao, V. Agrawal, F. Seker-Polat, E. L. Aiden, M. T. Kanemaki, V. Backman, M. Adli

This study shows that depleting lamins B1 and B2 changes chromatin mobility and gene expression through mesoscale-motion dependent mechanisms.

bioRxiv · Jun 26, 2023 · PreprintBioengineering

Preservation of cellular nano-architecture by the process of chemical fixation for nanopathology

X. Zhou, L. Almassalha, Y. Li, A. Eshein, L. Cherkezyan, P. Viswanathan, H. Subramanian, I. Szleifer, V. Backman

This study evaluates how cytological preparation affects nanoscale chromatin changes using PWS microscopy in cancer cell models, showing that modifications can preserve clinically relevant nanoscopic differences.

bioRxiv · Jul 18, 2018Biophysics