Author

N. Acosta

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 3 Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Assay:Hi-C· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

V. Backman· 3 shared E. M. Pujadas· 2 shared L. M. Almassalha· 2 shared M. T. Kanemaki· 2 shared A. D. Stephens· 1 shared A. Daneshkhah· 1 shared A. R. Shim· 1 shared C. L. Dunton· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

V. Backman

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3 papers

Recent·Most cited

Nuclear blebs are associated with destabilized chromatin packing domains

E. M. Pujadas Liwag, N. Acosta, L. M. Almassalha, Y. Su, R. Gong, M. T. Kanemaki, A. D. Stephens, V. Backman

The paper investigates how nuclear blebs alter chromatin packing domains, finding fragmentation of nanoscopic heterochromatin domains within blebs.

bioRxiv · Mar 28, 2024Bioengineering

Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure

A. R. Shim, J. Frederick, E. M. Pujadas, T. Kuo, I. C. Ye, J. A. Pritchard, C. L. Dunton, P. Carrillo Gonzalez, N. Acosta, S. Jain, N. M. Anthony, L. M. Almassalha, I. Szleifer, V. Backman

This study shows that formamide in 3D FISH distorts nanoscale chromatin structure, while alternative methods like RASER-FISH and CRISPR-Sirius have minimal impact.

bioRxiv · Mar 1, 2024Biophysics

Depletion of lamins B1 and B2 alters chromatin mobility and induces differential gene expression by a mesoscale-motion dependent mechanism

E. M. Pujadas, X. Wei, N. Acosta, L. Carter, J. Yang, L. Almassalha, A. Daneshkhah, S. S. P. Rao, V. Agrawal, F. Seker-Polat, E. L. Aiden, M. T. Kanemaki, V. Backman, M. Adli

This study shows that depleting lamins B1 and B2 changes chromatin mobility and gene expression through mesoscale-motion dependent mechanisms.

bioRxiv · Jun 26, 2023 · PreprintBioengineering