Author

L. Ciraku

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

M. J. Reginato· 2 shared A. A. Rashad· 1 shared A. Dick· 1 shared A. N. Talarico· 1 shared C. D. Katsetos· 1 shared C. M. Ferrer· 1 shared E. Esquea· 1 shared J. Beld· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

M. J. Reginato

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Discovery of novel brain permeable human ACSS2 inhibitors for blocking breast cancer brain metastatic growth

A. Dick, M. J. Reginato, J. Beld, N. L. Simone, S. Cocklin, A. A. Rashad, A. N. Talarico, J. Merzy, R. G. Young, L. Ciraku, E. Esquea

This study identifies and validates two novel ACSS2 inhibitors that cross the blood-brain barrier and reduce breast cancer brain metastasis in vitro and ex vivo.

bioRxiv · Dec 22, 2023 · PreprintCancer Biology

O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation

L. Ciraku, Z. A. Bacigalupa, J. Ju, R. A. Moeller, R. H. Lee, M. D. Smith, C. M. Ferrer, S. Trefely, M. T. Doan, W. A. Gocal, L. D'Agostino, W. Shi, J. G. Jackson, C. D. Katsetos, N. W. Snyder, M. J. Reginato

This study identifies OGT's role in regulating GBM acetate metabolism through CDK5-dependent ACSS2 phosphorylation, showing that targeting this pathway inhibits tumor growth.

bioRxiv · May 10, 2021Cancer Biology