O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation
L. Ciraku, Z. A. Bacigalupa, J. Ju, R. A. Moeller, R. H. Lee, M. D. Smith, C. M. Ferrer, S. Trefely, M. T. Doan, W. A. Gocal, L. D'Agostino, W. Shi, J. G. Jackson, C. D. Katsetos, N. W. Snyder, M. J. Reginato
This study identifies OGT's role in regulating GBM acetate metabolism through CDK5-dependent ACSS2 phosphorylation, showing that targeting this pathway inhibits tumor growth.
bioRxiv · May 10, 2021Cancer Biology