Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
L. T. Izzo, S. Trefely, C. Demetriadou, J. Drummond, T. Mizukami, N. Kuprasertkul, A. Farria, P. Nguyen, L. Reich, J. Shaffer, H. Affronti, A. Carrer, A. Andrews, B. C. Capell, N. W. Snyder, K. E. Wellen
This study identifies the carnitine shuttle and CrAT as a pathway for mitochondrial-to-cytosolic acetyl-CoA transfer, independent of ACLY, in cancer cells.
bioRxiv · Sep 24, 2022 · PreprintCell Biology
L. Ciraku, Z. A. Bacigalupa, J. Ju, R. A. Moeller, R. H. Lee, M. D. Smith, C. M. Ferrer, S. Trefely, M. T. Doan, W. A. Gocal, L. D'Agostino, W. Shi, J. G. Jackson, C. D. Katsetos, N. W. Snyder, M. J. Reginato
This study identifies OGT's role in regulating GBM acetate metabolism through CDK5-dependent ACSS2 phosphorylation, showing that targeting this pathway inhibits tumor growth.
bioRxiv · May 10, 2021Cancer Biology
S. L. Campbell, C. Mesaros, L. Izzo, H. Affronti, T. Tsang, M. Noji, B. E. Schaffer, K. Sun, S. Trefely, S. Kruijning, J. Blenis, I. A. Blair, K. E. Wellen
This study shows that glutamine deprivation in pancreatic ductal adenocarcinoma cells increases free GlcNAc and activates NAGK-dependent hexosamine salvage to support tumor growth.
bioRxiv · Sep 13, 2020Cancer Biology
W. Giblin, L. Bringman-Rodenbarger, A. H. Guo, S. Kumar, A. C. Monovich, A. M. Mostafa, M. E. Skinner, M. Azar, A. S. A. Mady, C. H. Chung, N. Kadambi, K.-A. Melong, H.-J. Lee, L. Zhang, P. Sajjakulnukit, , D. B. Lombard
This study identifies SIRT5 as essential for melanoma cell survival and tumor formation, showing it regulates chromatin dynamics and gene expression through histone modifications.
bioRxiv · Sep 7, 2020 · PreprintCancer Biology
S. Trefely, K. Huber, J. Liu, M. Noji, S. Stransky, J. Singh, M. Doan, C. D. Lovell, E. von Krusenstiern, H. Jiang, A. Bostwick, H. L. Pepper, L. Izzo, S. Zhao, J. P. Xu, , N. W. Snyder
The paper introduces SILEC-SF, a method for sub-cellular metabolomic analysis, and finds distinct nuclear acyl-CoA profiles with notable propionyl-CoA enrichment and a new metabolic pathway for histone propionylation.
bioRxiv · Jul 30, 2020 · PreprintBiochemistry
M. T. Doan, M. D. Neinast, E. L. Varner, K. Bedi, D. Bartee, H. Jiang, S. Trefely, P. Xu, J. P. Singh, C. Jiang, E. Rame, D. Brady, J. L. Meier, K. Marguiles, Z. Arany, N. W. Snyder
The paper confirms the in vivo synthesis of a six-carbon metabolite from propionate in human heart and mouse tissues through non-oxidative pathways.
bioRxiv · Jun 15, 2020 · PreprintBiochemistry
E. L. Varner, S. Trefely, D. Bartee, E. von Krusenstiern, L. Izzo, C. Bekeova, R. S. O'Connor, E. L. Seifert, K. Wellen, J. L. Meier, N. W. Snyder
This paper quantifies lactoyl-CoA in mammalian cells and tissues using LC-HRMS and provides a biosynthetic method for isotopically labeled lactoyl-CoA.
bioRxiv · Mar 15, 2020 · PreprintBiochemistry
S. Trefely, J. Liu, K. Huber, M. T. Doan, H. Jiang, J. Singh, E. von Krusenstiern, A. Bostwick, P. Xu, J. Bogner-Strauss, K. E. Wellen, N. W. Snyder
The paper corrects for artifactual post-harvest metabolism in subcellular isotope tracing to reveal compartment-specific metabolic kinetics.
bioRxiv · Aug 28, 2019Biochemistry
N. W. Snyder, S. Trefely, C. Mesaros, P. Xu, M. Doan, H. Jiang, O. Altinok, Z. Orynbayeva
The paper identifies an artefactual pyruvate formation from lactate during LC-MS analysis, highlighting the need for improved resolution or quantification in metabolomics studies.
bioRxiv · Apr 23, 2018Biochemistry