Author

L. Holmgren

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:development & morphogenesis· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Y. Zhang· 3 shared O. Bergman· 2 shared A. Fernandez-Corona· 1 shared A. J. Mannion· 1 shared B. Jimenez· 1 shared D. F. J. Ketelhuth· 1 shared D. K.-C. Chiu· 1 shared E. Hutterer· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersCell Biology

Y. Zhang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The junctional mechanosensor AmotL2 regulates YAP promotor accessibility

A. J. Mannion, H. Zhao, Y. Zhang, Y. von Wright, O. Bergman, P. Saharinen, L. Holmgren

This study shows AmotL2 regulates YAP promoter accessibility through chromatin remodeling in endothelial cells under mechanical stress.

bioRxiv · Jan 13, 2023 · PreprintCell Biology

p73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin

L. Maeso-Alonso, H. Alonso-Olivares, N. Martinez-Garcia, L. Lopez-Ferreras, J. Villoch-Fernandez, L. Puente-Santamaria, N. Colas-Algora, A. Fernandez-Corona, M. E. Lorenzo-Marcos, B. Jimenez, L. Holmgren, M. Wilhelm, J. Millan, L. del Peso, L. Claesson-Welsh, , M. C. Marin

This study identifies p73 as a regulator of endothelial junction dynamics through Angiomotin, showing its role in maintaining vessel integrity and preventing hyperpermeability.

bioRxiv · Mar 3, 2022Cell Biology

The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms

Y. Zhang, E. Hutterer, S. Hultin, O. Bergman, M. J. Forteza, Z. Andonovic, D. F. J. Ketelhuth, J. Roy, P. Eriksson, L. Holmgren

This study identifies the VE-cadherin/AmotL2 mechanosensory pathway as a suppressor of aortic inflammation and abdominal aortic aneurysms through mechanotransduction in endothelial cells.

bioRxiv · May 7, 2021Cell Biology

The Amot/Integrin protein complex transmits mechanical forces required for vascular expansion

Y. Zhang, Y. Zhang, S. Kameishi, G. Barutello, Y. Zheng, N. P. Tobin, J. Nicosia, K. Hennig, D. K.-C. Chiu, M. Balland, T. H. Barker, F. Cavallo, L. Holmgren

This study shows that Amot is essential for vascular expansion by transmitting mechanical forces through the integrin adhesome in mice.

bioRxiv · Jan 14, 2021Cell Biology