L. Jacob

BRCA1 expression, its correlation with clinicopathological features and response to neoadjuvant chemotherapy in high grade serous ovarian cancer from an Indian centre

Phyloformer: towards fast and accurate phylogeny estimation with self-attention networks

Phyloformer uses a transformer-based network to predict pairwise evolutionary distances from multiple sequence alignments, enabling accurate and faster phylogenetic tree reconstruction compared to traditional methods.

Mycobacterium tuberculosis genetic features associated with pulmonary tuberculosis severity

This study identifies Mtb genetic features linked to pulmonary tuberculosis severity using whole genome sequencing and genome-wide association analysis.

Endothelial Unc5B controls blood-brain barrier integrity

This study shows that endothelial Unc5B maintains blood-brain barrier integrity via Wnt/{beta}-catenin signaling, with potential therapeutic applications for CNS diseases.

SLIT2-ROBO signaling in tumor-associated microglia/macrophages drives glioblastoma immunosuppression and vascular dysmorphia

This study shows that SLIT2-ROBO signaling in tumor-associated microglia/macrophages promotes glioblastoma immunosuppression and vascular dysmorphia, and its inhibition reduces tumor growth and enhances therapy.

Within-host genetic micro-diversity of Mycobacterium tuberculosis and the link with tuberculosis disease features

The paper shows that genetic diversity within Mycobacterium tuberculosis isolates from the same patient correlates with TB severity and is driven by adaptation to infection sites.

Mass Spectrometric Characterization of Narcolepsy-Associated Pandemic 2009 Influenza Vaccines.

This study uses mass spectrometry to compare mutations in Pandemrix and Arepanrix vaccines, finding differences in protein modifications that may explain varying narcolepsy risks.