Author

L. Dethlefsen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:metagenomics· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. A. Relman· 3 shared E. Yaffe· 2 shared S. Holmes· 2 shared A. Aranda-Diaz· 1 shared A. Burns· 1 shared A. D. Patterson· 1 shared A. Gonzalez· 1 shared A. V. Patankar· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersEvolutionary Biology

D. A. Relman

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A short course of antibiotics selects for persistent resistance in the human gut

E. Yaffe, L. Dethlefsen, A. V. Patankar, C. Gui, S. Holmes, D. A. Relman

This study shows that short antibiotic use in humans leads to persistent resistance in gut bacteria through convergent evolution and selective sweeps.

bioRxiv · Sep 4, 2023 · PreprintEvolutionary Biology

Profiling of the human intestinal microbiome and bile acids under physiologic conditions using an ingestible sampling device

D. Shalon, R. N. Culver, J. A. Grembi, J. Folz, P. Treit, L. Dethlefsen, X. Meng, E. Yaffe, S. Spencer, H. Shi, A. Aranda-Diaz, A. D. Patterson, G. Triadafilopoulos, S. P. Holmes, M. Mann, , K. Huang

The paper develops an ingestible device to collect intestinal samples and identifies regional differences in microbiota and bile acids compared to stool.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Short-Term Dairy Elimination and Reintroduction Minimally Perturbs the Gut Microbiota in Self-Reported Lactose Intolerant Adults

C. J. Smith, L. Dethlefsen, C. Gardner, L. Nguyen, M. Feldman, E. K. Costello, O. Kolodny, D. A. Relman

This study examines the impact of short-term dairy elimination and reintroduction on gut microbiota and lactose tolerance in self-reported lactose intolerant adults, finding minimal microbiota changes and improved symptom tolerance.

bioRxiv · Oct 10, 2021 · PreprintMicrobiology

Microbial biogeography and ecology of the mouth and implications for periodontal diseases

D. Proctor, K. Shelef, A. Gonzalez, C. Long, L. Dethlefsen, A. Burns, P. Loomer, G. Armitage, M. Ryder, M. Millman, R. Knight, S. Holmes, D. A. Relman

This paper explores microbial biogeography in the human mouth, linking spatial patterns to periodontal diseases and proposing methods to test hypotheses about subgingival microbiota variation.

bioRxiv · Feb 8, 2019Ecology