Author

D. E. Goldberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 11

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:plant (other)· 6 Organism:human· 5 Research Focus:host-pathogen & immune response· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

A. J. Polino· 4 shared J. R. Beck· 3 shared A. B. Vaidya· 2 shared J. J. Miller· 2 shared S. Bhatnagar· 2 shared A. R. Odom John· 1 shared A. S. Nasamu· 1 shared B. Vaupel· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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4 shared papersMicrobiology

A. J. Polino

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11 papers

Recent·Most cited

The mature N termini of Plasmodium effector proteins confer specificity of export

M. M. Hasan, A. J. Polino, S. Mukherjee, B. Vaupel, D. E. Goldberg

This study shows that precise cleavage by signal peptidase to generate the mature N terminus is necessary for export of PEXEL proteins, while PM V cleavage is not required.

bioRxiv · May 17, 2023 · PreprintMicrobiology

A nepenthesin insert allosterically controls catalysis in the malaria parasite protease plasmepsin V

A. J. Polino, J. J. Miller, S. Bhakat, S. Bobba, G. R. Bowman, D. E. Goldberg

The paper identifies a nepenthesin insert essential for plasmepsin V function in malaria parasites and shows it allosterically regulates catalysis.

bioRxiv · Feb 28, 2022 · PreprintMicrobiology

An essential ER-resident N-acetyltransferase in Plasmodium falciparum

A. J. Polino, K. Floyd, Y. Avila-Cruz, Y. Yang, D. E. Goldberg

The paper identifies an ER-resident N-acetyltransferase in Plasmodium falciparum essential for parasite growth but not for protein export or acetylation of specific exported proteins.

bioRxiv · Nov 1, 2021 · PreprintMicrobiology

Enzymatic and structural characterization of HAD5, an essential phosphomannomutase of malaria parasites

P. M. Frasse, J. J. Miller, E. Soleimani, J.-S. Zhu, D. L. Jakeman, J. M. Jez, D. E. Goldberg, A. R. Odom John

This study characterizes HAD5, a phosphomannomutase essential for GPI anchor biosynthesis in malaria parasites, showing its role in parasite egress and reinvasion and identifying a specific inhibitor.

bioRxiv · Jul 3, 2021Microbiology

EXP1 is required for organization of the intraerythrocytic malaria parasite vacuole

T. Nessel, J. M. Beck, S. Rayatpisheh, Y. Jami-Alahmadi, J. A. Wohlschlegel, D. E. Goldberg, J. R. Beck

This study investigates the role of EXP1 in maintaining the structure of the malaria parasite's parasitophorous vacuole using CRISPR/Cpf1 and BioID2, revealing its critical function in vacuole organization.

Cellular Microbiology · Feb 12, 2020Peer-reviewedMicrobiology

Contacting domains that segregate lipid from solute transporters in malaria parasites

M. Garten, J. R. Beck, R. Roth, T. Tenkova-Heuser, J. Heuser, C. K. Bleck, D. E. Goldberg, J. Zimmerberg

The paper identifies membrane contact sites between the parasitophorous vacuolar membrane and parasite plasma membrane in malaria parasites, showing distinct localization of nutrient and lipid transporters.

bioRxiv · Dec 6, 2019Microbiology

Diverse chemical compounds target Plasmodium falciparum plasma membrane lipid homeostasis

S. Bhatnagar, S. Nicklas, J. M. Morrisey, D. E. Goldberg, A. B. Vaidya

The paper screens compounds to identify those disrupting Plasmodium falciparum plasma membrane lipid homeostasis, finding some act independently of Na+ homeostasis and target PfNCR1.

bioRxiv · Oct 16, 2018Microbiology

Assessment of biological role and insight into druggability of the Plasmodium falciparum protease plasmepsin V

D. E. Goldberg, J. Niles, A. J. Polino, A. S. Nasamu

This paper validates plasmepsin V as an essential malaria parasite protein by showing its depletion arrests parasite growth and reveals an unexpected role in early development.

bioRxiv · Sep 26, 2018Microbiology

Plasmodium falciparum Niemann-Pick Type C1-Related Protein is a Druggable Target Required for Parasite Membrane Homeostasis

E. S. Istvan, S. Das, S. Bhatnagar, J. R. Beck, E. Owen, M. LLinas, S. M. Ganesan, J. C. Niles, E. A. Winzeler, A. B. Vaidya, D. E. Goldberg

This study identifies PfNCR1 as a critical protein for Plasmodium falciparum membrane homeostasis and shows it is a potential druggable target for antimalarial drugs.

bioRxiv · Jul 26, 2018Microbiology

Evaluation of current and emerging anti-malarial medicines for inhibition of Toxoplasma gondii growth in vitro

J. B. Radke, J. N. Burrows, D. E. Goldberg, L. D. Sibley

This study evaluates anti-malarial drugs for their ability to inhibit Toxoplasma gondii growth in vitro, finding limited effectiveness for most compounds.

bioRxiv · May 8, 2018Microbiology

Plasmodium falciparum dipeptidyl aminopeptidase 3 activity is important for efficient erythrocyte invasion by the malaria parasite

C. Lehmann, M. S. Y. Tan, L. E. de Vries, I. Russo, M. I. Sanchez, D. E. Goldberg, E. Deu

This study shows that DPAP3 protease activity is crucial for Plasmodium falciparum erythrocyte invasion but not egress.

bioRxiv · Nov 8, 2017Microbiology