L. F. Risnes

Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease

The paper identifies circulating TG2-specific IgA cells in celiac disease patients, showing they are clonally related to intestinal plasma cells and generated via an extrafollicular response involving gluten-specific CD4+ T cells.

Resident memory CD8 T cells persist for years in human small intestine

The paper identifies that most CD8 T cells in the human small intestine are resident memory cells that persist for over a year and maintain a stable TCR repertoire.