K. E. A. Lundin

Gene expression and eQTL analysis reflect the heterogeneity in the inflammatory status of the duodenal epithelial lining in coeliac disease

This study identifies gene expression patterns and eQTLs in duodenal epithelial lining of coeliac disease patients that reflect inflammation status and disease condition.

Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease

The paper identifies circulating TG2-specific IgA cells in celiac disease patients, showing they are clonally related to intestinal plasma cells and generated via an extrafollicular response involving gluten-specific CD4+ T cells.

Separate Gut Plasma Cell Populations Produce Autoantibodies Against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis

The paper identifies separate gut plasma cell populations in DH patients producing autoantibodies specific to TG2 and TG3 with no cross-reactivity.

Titers of antibodies the receptor-binding domain (RBD) of ancestral SARS-CoV-2 are predictive for levels of neutralizing antibodies to multiple variants

This study shows that anti-RBDwt titers correlate with neutralizing antibody levels against multiple SARS-CoV-2 variants and proposes a method to improve immunomonitoring precision and throughput.

Antibodies to native gluten arise from cross-reactive B cells with implications for epitope spreading in celiac disease

The paper identifies a new native gluten epitope recognized by cross-reactive B cells in celiac disease, which may contribute to epitope spreading.

Affinity-engineered human antibodies detect celiac disease gluten pMHC complexes and inhibit T-cell activation

The paper describes the engineering of high-affinity human antibodies that recognize gluten epitopes bound to HLA-DQ2.5 and inhibit T-cell activation in celiac disease.

Machine learning analysis of naïve B-cell receptor repertoires stratifies celiac disease patients and controls

The paper uses machine learning to analyze naive B-cell receptor repertoires to distinguish celiac disease patients from controls, achieving an F1 score of 85%.

The human small intestine contains two subsets of regulatory Foxp3+ CD4+ T cells with very different life span and functional properties.

This study identifies two distinct subsets of Foxp3+ CD4+ Tregs in the human small intestine with different functional properties and lifespans, which expand in celiac disease.