L. M. Sollid

Generation of circulating autoreactive pre-plasma cells fueled by naive B cells in celiac disease

The paper identifies circulating TG2-specific IgA cells in celiac disease patients, showing they are clonally related to intestinal plasma cells and generated via an extrafollicular response involving gluten-specific CD4+ T cells.

Weakly supervised identification and generation of adaptive immune receptor sequences associated with immune disease status

The paper develops AIRRTM, a generative model that identifies and generates disease-associated adaptive immune receptor sequences using only repertoire-level immune status data.

Separate Gut Plasma Cell Populations Produce Autoantibodies Against Transglutaminase 2 and Transglutaminase 3 in Dermatitis Herpetiformis

The paper identifies separate gut plasma cell populations in DH patients producing autoantibodies specific to TG2 and TG3 with no cross-reactivity.

Antibodies to native gluten arise from cross-reactive B cells with implications for epitope spreading in celiac disease

The paper identifies a new native gluten epitope recognized by cross-reactive B cells in celiac disease, which may contribute to epitope spreading.

Human KIR+CD8+ T cells target pathogenic T cells in Celiac disease and are active in autoimmune diseases and COVID-19

The paper identifies KIR+CD8+ T cells as regulatory cells in humans that suppress pathogenic CD4+ T cells in autoimmune and infectious diseases.

Affinity-engineered human antibodies detect celiac disease gluten pMHC complexes and inhibit T-cell activation

The paper describes the engineering of high-affinity human antibodies that recognize gluten epitopes bound to HLA-DQ2.5 and inhibit T-cell activation in celiac disease.

Stereotyped B-cell responses are linked to IgG constant region polymorphisms in multiple sclerosis

This study links IgG constant region polymorphisms to stereotyped B-cell responses in multiple sclerosis by analyzing clonal relationships and isotype distributions in intrathecal B-lineage cells.

Individualized VDJ recombination predisposes the available Ig sequence space

The paper shows that VDJ recombination rules vary between individuals, leading to individual-specific Ig sequence spaces.

Machine learning analysis of naïve B-cell receptor repertoires stratifies celiac disease patients and controls

The paper uses machine learning to analyze naive B-cell receptor repertoires to distinguish celiac disease patients from controls, achieving an F1 score of 85%.

Longevity, clonal relationship and transcriptional program of celiac disease-specific plasma cells

The paper analyzes single-cell RNA-seq data from plasma cells in celiac disease patients to identify transcriptional differences and clonal relationships between disease-specific and non-specific plasma cells.

Polymorphisms in immunoglobulin heavy chain variable genes and their upstream regions

The paper identifies novel germline IGHV alleles and upstream sequence variability, challenging current immunoglobulin repertoire annotation methods.

Resident memory CD8 T cells persist for years in human small intestine

The paper identifies that most CD8 T cells in the human small intestine are resident memory cells that persist for over a year and maintain a stable TCR repertoire.