Author

L. G. Holden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Ashish· 1 shared A. B. Ward· 1 shared A. Chandrawacar· 1 shared A. K. Srikrishnan· 1 shared B. S. Stephens· 1 shared C. A. Cottrell· 1 shared D. Sok· 1 shared G. Ozorowski· 1 shared

Activity by Year

2020-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperImmunology

A. Ashish

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2 papers

Recent·Most cited

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

R. Kumar, S. Deshpande, L. M. Sewall, G. Ozorowski, C. A. Cottrell, W.-H. Lee, L. G. Holden, S. T. Richey, A. Chandrawacar, K. Dhiman, A. Ashish, V. Kumar, S. Ahmed, N. Hingankar, N. Kumar, , J. Bhattacharya

This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.

PLOS Pathogens · Apr 7, 2021Peer-reviewedImmunology

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

T. Ngo, B. S. Stephens, M. Gustavsson, L. G. Holden, R. Abagyan, T. M. Handel, I. Kufareva

This paper determines the structure of the CXCR4-CXCL12 complex using crosslinking, revealing the geometry and selectivity determinants of CXC receptor-chemokine interactions.

bioRxiv · Jan 10, 2020Biochemistry