S. T. Richey

Immune memory shapes human polyclonal antibody responses to H2N2 vaccination

This study examines how prior H2 influenza exposure influences polyclonal antibody responses to H2N2 vaccination, showing differences in epitope targeting between H2-exposed and H2-naive individuals.

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.

A public broadly neutralizing antibody class targets a membrane-proximal anchor epitope of influenza virus hemagglutinin

This study identifies a class of broadly neutralizing antibodies targeting a conserved membrane-proximal epitope on influenza HA, showing their induction by a chimeric HA vaccine.

Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization

This study shows that off-target antibodies from HIV trimer vaccines cause trimer disassembly, exposing more off-target epitopes and driving further off-target immune responses.

Polyclonal epitope cartography reveals the temporal dynamics and diversity of human antibody responses to H5N1 vaccination

This study uses EMPEM to track human antibody responses to H5N1 vaccination, showing persistent stem-binding antibodies and transient head-binding antibodies after immunization.