L. M. Sewall

Anti-Immune Complex Antibodies are Elicited During Repeated Immunization with HIV Env Immunogens

The paper identifies anti-immune complex antibodies generated through repeated HIV Env immunizations and presents their structures using polyclonal epitope mapping.

Germline-targeting SOSIP trimer immunization elicits precursor CD4 binding-site targeting broadly neutralizing antibodies in infant macaques.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

Focusing antibody responses to the fusion peptide in rhesusmacaques

This study uses continuous immunogen delivery in rhesus macaques to focus antibody responses on the HIV fusion peptide, identifying key residues for vaccine design.

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

This study identifies nAbs against SIVmac239, reveals structural features of its Env trimer, and shows passive transfer of nAbs protects macaques from infection.

Long-lasting germinal center responses to a priming immunization with continuous proliferation and somatic mutation

This study shows that germinal center B cells can persist and continue to mutate for 29 weeks after a single immunization, leading to long-lasting antibody responses.

Structural mapping of antibody landscapes to human betacoronavirus spike proteins

The paper maps epitopes of polyclonal antibodies against beta-coronavirus spike proteins in human sera, revealing cross-reactive patterns between seasonal and SARS-2 infections.

From Structure to Sequence: Identification of polyclonal antibody families using cryoEM

This paper uses cryoEM and next-generation sequencing to identify monoclonal antibodies from polyclonal sera and validate their antigen-binding properties.

Elicitation of potent serum neutralizing antibody responses in rabbits by immunization with an HIV-1 clade C trimeric Env derived from an Indian elite neutralizer

This study shows that immunization with a thermostable HIV-1 clade C Env trimer induces potent autologous neutralizing antibodies in rabbits, with distinct epitope specificity compared to natural infection.

Polyclonal antibody responses to HIV Env immunogens resolved using cryoEM

The paper uses cryoEM to analyze polyclonal antibody responses to HIV Env immunogens in rhesus macaques, revealing structural differences in antibody binding and immunogenicity of engineered mutations and glycan sites.

Mapping the immunogenic landscape of near-native HIV-1 envelope trimers in non-human primates

This study maps antibody responses to HIV-1 envelope trimers in non-human primates, identifying strain-specific and conserved epitopes recognized by vaccine-induced antibodies.

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

The paper evaluates de novo-designed two-component nanoparticles for presenting HIV Env trimers, showing improved antibody responses through multivalent display.

Mapping polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines

This study maps polyclonal antibody responses in non-human primates vaccinated with HIV Env trimer subunit vaccines and identifies epitopes associated with neutralization breadth.