Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility
F. Sanchez-Saez, L. Gomez-H, O. M. Dunne, C. Gallego-Paramo, N. Felipe-Medina, M. A. Sanchez-Martin, E. Llano, A. M. Pendas, O. R. Davies
This study identifies SYCE1-SIX6OS1 interactions critical for meiotic synapsis, showing that mutations disrupting these interactions cause human infertility.
bioRxiv · Feb 4, 2020Biochemistry