Author

L. Harkema

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. de Bruin· 2 shared C. F. Calkhoven· 1 shared C. Müller· 1 shared D. S. Verbeek· 1 shared F. Foijer· 1 shared G. Kortman· 1 shared J. P. Tuckermann· 1 shared J. von Maltzahn· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCancer Biology

A. de Bruin

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2 papers

Recent·Most cited

Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice

K. M. Schukken, Y. Zhu, P. L. Bakker, L. Harkema, S. A. Youssef, A. de Bruin, F. Foijer

This study shows that acute systemic loss of Mad2 in adult mice causes intestinal atrophy, weight loss, and death within 10 days due to high-grade CIN, with minimal effects on other tissues.

bioRxiv · Dec 3, 2020Cancer Biology

Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice

C. Müller, L. M. Zidek, T. Ackermann, T. de Jong, P. Liu, V. Kliche, M. A. Zaini, G. Kortman, L. Harkema, D. S. Verbeek, J. P. Tuckermann, J. von Maltzahn, A. de Bruin, Z.-Q. Wang, V. Guryev, C. F. Calkhoven

This study shows that reducing C/EBPβ-LIP expression in mice delays age-related phenotypes and extends lifespan, suggesting therapeutic potential for age-related diseases.

bioRxiv · Jan 18, 2018Cell Biology