Author

L. Iselin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Castello· 2 shared I. Davis· 2 shared A. Csala· 1 shared A. De'Felice· 1 shared A. Embarc-Buh· 1 shared A. I. Jarvelin· 1 shared A. Järvelin· 1 shared A. Merits· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. Castello

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Alphavirus infection triggers selective cytoplasmic translocation of nuclear RBPs with moonlighting antiviral roles

W. Kamel, V. Ruscica, A. Embarc-Buh, Z. R. de Laurent, M. Garcia-Moreno, Y. Demyanenko, M. Madhusudhan, L. Iselin, A. Järvelin, M. Hannan, E. Kitano, S. Moore, A. Merits, I. Davis, S. Mohammed, A. Castello

This study identifies nuclear RNA-binding proteins that are translocated to the cytoplasm during alphavirus infection and exhibit antiviral activity.

bioRxiv · Oct 6, 2021Microbiology

Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences

J. Y. Lee, P. A. Wing, D. S. Gala, M. Noerenberg, A. I. Jarvelin, J. Titlow, X. Zhuang, N. Palmalux, L. Iselin, M. K. Thompson, R. M. Parton, A. Wainman, D. Agranoff, W. James, A. Castello, , I. Davis

The paper quantifies SARS-CoV-2 RNA molecules using smFISH, revealing genomic RNA stability, cell-to-cell replication variability, and slower replication kinetics for the B.1.1.7 variant compared to the Victoria strain.

bioRxiv · Jun 29, 2021Microbiology

Low Replication Capacity Virus Is Preferentially Transmitted In Mother-To-Child-Transmission But Not In Adult-To-Adult-Transmission Of HIV-1

E. Adland, L. Iselin, F. Roxburgh, J. Millar, A. Csala, V. Naidoo, C. Noble, J. Thomas, A. De'Felice, A. Szabo, N. Grayson, A. Moodley, K. Dong, B. Walker, T. Ndung'u, , P. Goulder

The paper compares viral replicative capacity in mother-to-child and adult-to-adult HIV-1 transmission, finding lower replicative capacity in MTCT viruses.

bioRxiv · Jan 3, 2019 · PreprintImmunology