Author

M. K. Thompson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:chromatin & epigenetic regulation· 2 Organism:Drosophila· 2 Assay:spatial transcriptomics· 2 Assay:structural biology· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

I. Davis· 3 shared D. S. Gala· 2 shared J. Y. Lee· 2 shared R. M. Parton· 2 shared A. Castello· 1 shared A. Ceccarelli· 1 shared A. Dallman-Porter· 1 shared A. I. Jarvelin· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBiochemistry

I. Davis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Unique Binding and Stabilization Mechanisms Employed By and Engineered Into Nanobodies.

N. E. Ketaren, P. C. Fridy, V. Malashkevich, T. Sanyal, M. Brilliantes, M. K. Thompson, D. A. Orens, J. B. Bonanno, a. Sali, S. C. Almo, B. T. Chait, M. P. Rout

This study identifies mechanisms enabling nanobodies to bind antigens with high affinity and stability, revealing a conserved region critical for their function and suggesting strategies for their optimization.

bioRxiv · Oct 22, 2023 · PreprintBiochemistry

Deciphering the orthorhombic crystal structure of a novel NEIL1 nanobody with pseudo-merohedral twinning

M. K. Thompson, N. Sharma, A. Prakash

The paper determines the orthorhombic crystal structure of a NEIL1-specific nanobody at 2.1 Å resolution, revealing pseudo-merohedral twinning and resolving over 96% of residues.

bioRxiv · Aug 7, 2023 · PreprintBiochemistry

Dynamically regulated transcription factors are encoded by highly unstable mRNAs in the Drosophila larval brain

M. K. Thompson, A. Ceccarelli, D. Ish-Horowicz, I. Davis

The paper measures RNA synthesis and decay rates in Drosophila larval brains, finding that transient transcription factor mRNAs are highly unstable and epigenetically silenced.

bioRxiv · Dec 3, 2022Biochemistry

Systematic analysis of YFP gene traps reveals common discordance between mRNA and protein across the nervous system

J. S. Titlow, M. Kiourlappou, A. Palanca, J. Y. Lee, D. S. Gala, D. Ennis, J. J. S. Yu, F. L. Young, D. M. S. Pinto, S. Garforth, H. S. Francis, F. Strivens, H. Mulvey, A. Dallman-Porter, S. Thornton, , I. Davis

The paper systematically analyzes YFP gene traps in Drosophila to show widespread discordance between mRNA and protein expression in the nervous system, revealing common post-transcriptional regulation.

bioRxiv · Mar 21, 2022 · PreprintCell Biology

Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences

J. Y. Lee, P. A. Wing, D. S. Gala, M. Noerenberg, A. I. Jarvelin, J. Titlow, X. Zhuang, N. Palmalux, L. Iselin, M. K. Thompson, R. M. Parton, A. Wainman, D. Agranoff, W. James, A. Castello, , I. Davis

The paper quantifies SARS-CoV-2 RNA molecules using smFISH, revealing genomic RNA stability, cell-to-cell replication variability, and slower replication kinetics for the B.1.1.7 variant compared to the Victoria strain.

bioRxiv · Jun 29, 2021Microbiology