Author

L. J. Aponte-Collazo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. M. J. Fennell· 2 shared H. Ashamalla· 2 shared L. M. Graves· 2 shared P. R. Graves· 2 shared S. Lipkowitz· 2 shared Y. E. Greer· 2 shared A. A. Iwanowicz· 1 shared C. J. Der· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

E. M. J. Fennell

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 11, 2022

SMALL MOLECULE CLPP AGONISTS INDUCE SENESCENCE AND ALTER TRAIL-MEDIATED APOPTOTIC RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS

L. J. Aponte-Collazo, E. M. J. Fennell, M. P. East…·L. M. Graves

This paper shows that ClpP activators induce senescence in triple-negative breast cancer cells and enhance their sensitivity to TRAIL-mediated apoptosis.

DOI 10.1101/2022.07.11.499620

humanbulk RNA-seq

𝕏 PostBluesky

Pharmacology & ToxicologybioRxivFeb 14, 2022

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

E. M. J. Fennell, L. J. Aponte-Collazo, J. D. Wynn…·L. M. Graves

This paper characterizes TR-107, a novel ClpP activator, showing potent antitumor effects against triple-negative breast cancer through mitochondrial metabolic disruption.

DOI 10.1002/prp2.993

humanbulk RNA-seq

𝕏 PostBluesky