Author

Y. E. Greer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

E. M. J. Fennell· 3 shared L. M. Graves· 3 shared S. Lipkowitz· 3 shared E. Iwanowicz· 2 shared H. Ashamalla· 2 shared L. J. Aponte-Collazo· 2 shared P. R. Graves· 2 shared A. A. Iwanowicz· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

E. M. J. Fennell

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3 papers

Recent·Most cited

SMALL MOLECULE CLPP AGONISTS INDUCE SENESCENCE AND ALTER TRAIL-MEDIATED APOPTOTIC RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS

L. J. Aponte-Collazo, E. M. J. Fennell, M. P. East, T. S. K. Gilbert, P. R. Graves, H. Ashamalla, E. Iwanowicz, Y. E. Greer, S. Lipkowitz, L. M. Graves

This paper shows that ClpP activators induce senescence in triple-negative breast cancer cells and enhance their sensitivity to TRAIL-mediated apoptosis.

bioRxiv · Jul 11, 2022 · PreprintCancer Biology

Mitochondrial Matrix Protease ClpP Agonists inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

Y. E. Greer, L. Hernandez, E. M. J. Fennell, D. Voeller, R. Chari, S. F. Gilbert, B. Tang, M. Hafner, C. Annunziata, E. Iwanowicz, L. M. Graves, S. Lipkowitz

This study shows that ClpP agonists inhibit breast cancer stem cell function by disrupting mitochondrial homeostasis and multiple metabolic pathways.

bioRxiv · Mar 18, 2022Cancer Biology

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

E. M. J. Fennell, L. J. Aponte-Collazo, J. D. Wynn, K. Drizyte-Miller, E. Leung, Y. E. Greer, P. R. Graves, A. A. Iwanowicz, H. Ashamalla, E. Holmuhamedov, H. Lang, D. S. Karanewsky, C. J. Der, W. A. Houry, S. Lipkowitz, , L. M. Graves

This paper characterizes TR-107, a novel ClpP activator, showing potent antitumor effects against triple-negative breast cancer through mitochondrial metabolic disruption.

bioRxiv · Feb 14, 2022Pharmacology & Toxicology