Author

P. R. Graves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. M. J. Fennell· 2 shared H. Ashamalla· 2 shared L. J. Aponte-Collazo· 2 shared L. M. Graves· 2 shared S. Lipkowitz· 2 shared Y. E. Greer· 2 shared A. A. Iwanowicz· 1 shared C. J. Der· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

E. M. J. Fennell

Mutual co-authors in cluster

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2 papers

Recent·Most cited

SMALL MOLECULE CLPP AGONISTS INDUCE SENESCENCE AND ALTER TRAIL-MEDIATED APOPTOTIC RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS

L. J. Aponte-Collazo, E. M. J. Fennell, M. P. East, T. S. K. Gilbert, P. R. Graves, H. Ashamalla, E. Iwanowicz, Y. E. Greer, S. Lipkowitz, L. M. Graves

This paper shows that ClpP activators induce senescence in triple-negative breast cancer cells and enhance their sensitivity to TRAIL-mediated apoptosis.

bioRxiv · Jul 11, 2022 · PreprintCancer Biology

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

E. M. J. Fennell, L. J. Aponte-Collazo, J. D. Wynn, K. Drizyte-Miller, E. Leung, Y. E. Greer, P. R. Graves, A. A. Iwanowicz, H. Ashamalla, E. Holmuhamedov, H. Lang, D. S. Karanewsky, C. J. Der, W. A. Houry, S. Lipkowitz, , L. M. Graves

This paper characterizes TR-107, a novel ClpP activator, showing potent antitumor effects against triple-negative breast cancer through mitochondrial metabolic disruption.

bioRxiv · Feb 14, 2022Pharmacology & Toxicology