Author

L. M. Graves

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Organism:human· 6 Research Focus:cancer & tumor microenvironment· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

E. M. J. Fennell· 3 shared S. Lipkowitz· 3 shared Y. E. Greer· 3 shared C. J. Der· 2 shared E. Iwanowicz· 2 shared H. Ashamalla· 2 shared L. E. Herring· 2 shared L. J. Aponte-Collazo· 2 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

E. M. J. Fennell

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

SMALL MOLECULE CLPP AGONISTS INDUCE SENESCENCE AND ALTER TRAIL-MEDIATED APOPTOTIC RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER CELLS

L. J. Aponte-Collazo, E. M. J. Fennell, M. P. East, T. S. K. Gilbert, P. R. Graves, H. Ashamalla, E. Iwanowicz, Y. E. Greer, S. Lipkowitz, L. M. Graves

This paper shows that ClpP activators induce senescence in triple-negative breast cancer cells and enhance their sensitivity to TRAIL-mediated apoptosis.

bioRxiv · Jul 11, 2022 · PreprintCancer Biology

Mitochondrial Matrix Protease ClpP Agonists inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

Y. E. Greer, L. Hernandez, E. M. J. Fennell, D. Voeller, R. Chari, S. F. Gilbert, B. Tang, M. Hafner, C. Annunziata, E. Iwanowicz, L. M. Graves, S. Lipkowitz

This study shows that ClpP agonists inhibit breast cancer stem cell function by disrupting mitochondrial homeostasis and multiple metabolic pathways.

bioRxiv · Mar 18, 2022Cancer Biology

Characterization of TR-107, a Novel Chemical Activator of the Human Mitochondrial Protease ClpP

E. M. J. Fennell, L. J. Aponte-Collazo, J. D. Wynn, K. Drizyte-Miller, E. Leung, Y. E. Greer, P. R. Graves, A. A. Iwanowicz, H. Ashamalla, E. Holmuhamedov, H. Lang, D. S. Karanewsky, C. J. Der, W. A. Houry, S. Lipkowitz, , L. M. Graves

This paper characterizes TR-107, a novel ClpP activator, showing potent antitumor effects against triple-negative breast cancer through mitochondrial metabolic disruption.

bioRxiv · Feb 14, 2022Pharmacology & Toxicology

The ataxia protein sacsin is required for integrin trafficking and synaptic organization

L. E. L. Romano, W. Y. Aw, K. M. Hixson, T. V. Novoselova, T. M. Havener, S. Howell, C. L. Hall, L. Xing, J. Beri, S. Nethisinghe, L. Perna, A. Hatimy, G. Chioccioli Altadonna, L. M. Graves, L. E. Herring, , J. M. Wolter

This study identifies sacsin's role in integrin trafficking and synaptic organization, showing its deficiency causes cellular phenotypes in ARSACS.

bioRxiv · Aug 20, 2021 · PreprintCell Biology

Defining the KRAS-regulated kinome in KRAS-mutant pancreatic cancer

J. N. Diehl, J. E. Klomp, K. R. Snare, D. R. Blake, P. S. Hibshman, Z. D. Kaiser, T. S. K. Gilbert, E. Baldelli, M. Pierobon, B. Papke, R. Yang, R. G. Hodge, N. U. Rashid, E. F. Petricoin, L. E. Herring, , C. J. Der

This study identifies upregulated and downregulated kinases in KRAS-mutant pancreatic cancer using chemical proteomics, revealing potential therapeutic targets.

bioRxiv · Apr 27, 2021 · PreprintCancer Biology

Proteomic Analysis Defines Kinase Taxonomies Specific For Subtypes Of Breast Cancer

K. A. Collins, T. J. Stuhlmiller, J. S. Zawistowski, M. P. East, T. T. Pham, C. R. Hall, D. R. Goulet, S. M. Bevill, S. P. Angus, S. H. Velarde, N. Sciaky, T. I. Oprea, L. M. Graves, G. L. Johnson, S. M. Gomez

The paper uses proteomic analysis to define kinase taxonomies specific to breast cancer subtypes, revealing understudied kinases and their functional integration into signaling subnetworks.

bioRxiv · Sep 15, 2017Cancer Biology