L. J. Lee

mTOR-regulated Mitochondrial Metabolism Limits Mycobacterium-induced Cytotoxicity

This study identifies mTOR as a host factor that protects macrophages from Mycobacterium-induced death by regulating mitochondrial metabolism.

Engineering a Single Extracellular Vesicle Protein and RNA Assay (siEVPRA) via In Situ Fluorescence Microscopy in a UV Micropatterned Array

The paper introduces siEVPRA, a method to detect proteins, mRNAs, and miRNAs in single EVs using fluorescence microscopy, showing high sensitivity and clinical utility in GBM samples.

An Immunogold Single Extracellular Vesicular RNA and Protein (AuSERP) Biochip to Predict Responses to Immunotherapy in Non-Small Cell Lung Cancer Patients

The paper introduces an AuSERP biochip to detect single extracellular vesicle RNA and protein biomarkers for predicting immunotherapy responses in NSCLC patients, showing higher sensitivity than traditional methods.

Immunomagnetic Sequential Ultrafiltration (iSUF) Platform for Enrichment and Purification of Extracellular Vesicles from Biofluids

The paper introduces an iSUF platform to enrich and purify tumor-derived extracellular vesicles from biofluids, showing high enrichment and biomarker expression in clinical samples.

The co-stimulation of anti-CD28 and IL-2 enhances the sensitivity of ELISPOT assays for detection of neoantigen-specific T cells in PBMC

This paper improves ELISPOT assay sensitivity for detecting neoantigen-specific T cells by co-stimulating with anti-CD28 and IL-2, increasing detection by up to 5-fold.