G. Schoehn

R6G narrows BmrA conformational spectrum for a more efficient use of ATP

This study shows that Rhodamine6G binding to BmrA narrows its conformational spectrum, enhancing ATP-dependent transport efficiency.

Structural Determinants for Activity of the Antidepressant Vortioxetine at Human and Rodent 5-HT3 receptors

This study investigates how vortioxetine interacts with human and rodent 5-HT3 receptors, revealing structural differences and mechanisms of action.

Ultrastructural details of resistance factors of the bacterial spore revealed by in situ cryo-electron tomography

This study uses cryo-electron tomography to reveal the ultrastructural organization of Bacillus subtilis spores, including the toroidal chromosome and nascent coat layers during sporulation.

Antigen self-anchoring onto bacteriophage T5 capsid-like particles for vaccine design

This paper develops a vaccine platform using bacteriophage T5 capsid-like particles to display antigens, showing strong immune responses without adjuvants.

Deciphering bacteriophage T5 host recognition mechanism and infection trigger

This study determines the structure of bacteriophage T5 RBPpb5 bound to its E. coli receptor FhuA, revealing the mechanism of host recognition and infection initiation.

Structural basis of bacteriophage T5 infection trigger and E. coli cell wall perforation

This paper presents the structure of bacteriophage T5 tip and its interaction with E. coli receptor FhuA, revealing conformational changes during infection and cell wall perforation.

The F-box cofactor UFO redirects the LEAFY floral regulator to novel cis-elements

This study identifies a novel mechanism by which the F-box protein UFO modulates the DNA-binding specificity of the master transcription factor LFY through direct interaction with novel cis-elements.

Structural basis of CHMP2A-CHMP3 ESCRT-III polymer assembly and membrane cleavage

This study presents cryo-EM structures of CHMP2A-CHMP3 ESCRT-III filaments and shows they constrict and cleave membrane tubes through electrostatic interactions and VPS4-mediated remodeling.

Structural Basis for the Inhibition of IAPP Fibril Formation by the Hsp60 Co-Chaperonin Prefoldin

This study shows how prefoldin inhibits IAPP fibril formation by binding to the N-terminal segment of IAPP on fibril surfaces and ends, reducing aggregate size and number.

Elicitation of potent SARS-CoV-2 neutralizing antibody responses through immunization using a versatile adenovirus-inspired multimerization platform

This paper describes a vaccine platform using adenovirus-inspired nanoparticles decorated with SARS-CoV-2 RBD to elicit potent neutralizing antibodies in mice.

Reversible supramolecular assembly of the anti-microbial peptide plectasin into helical non-amyloid fibrils

The paper shows that a triple-mutant of plectasin forms reversible helical non-amyloid fibrils, with high-resolution structure and pH-dependent equilibrium.

Immunization with synthetic SARS-CoV-2 S glycoprotein virus-like particles protects Macaques from infection

This study develops a synthetic SARS-CoV-2 S glycoprotein virus-like particle vaccine that protects macaques from infection through strong antibody and T cell responses.

Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription

This study uses cryo-EM to reveal the structural dynamics of La Crosse virus polymerase, elucidating mechanisms of replication and transcription in Peribunyaviridae.

Immediate and sustained effects of cobalt and zinc-containing pigments on macrophages

This study examines the immediate and sustained effects of cobalt- and zinc-based pigments on macrophages, revealing functional disorders that persist even at non-toxic doses.

Nonclassical nucleation of protein mesocrystals via oriented attachment

The paper observes oriented attachment in protein crystallization, challenging previous classifications and showing non-classical nucleation mechanisms.

DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection and can be inhibited by a glycomimetic antagonist

The paper shows DC/L-SIGN receptors on antigen-presenting cells enhance SARS-CoV-2 trans-infection, which can be blocked by a glycomimetic compound.

Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

This study presents the cryo-EM structures of La Crosse virus polymerase in pre-initiation and elongation states, revealing conformational changes important for transcription.

In-cell quantitative structural imaging of phytoplankton using 3D electron microscopy

This paper develops a 3D electron microscopy workflow to generate nanometric phytoplankton models and identifies conserved subcellular features related to energy management.

Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex

The paper integrates NMR and cryo-EM to determine the atomic structure of a large enzyme complex, achieving high precision and accuracy beyond the limitations of each method individually.

Cryo-EM structure of adenovirus type 3 fibre with desmoglein 2 shows a novel mode of receptor engagement

The paper determines the cryo-EM structure of a complex between adenovirus type 3 fibre knob and desmoglein 2, revealing a novel receptor engagement mechanism.