Author

J. H. Hwang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Zoology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1

Frequent Co-Authors

H. E. Bergom· 2 shared J. M. Drake· 2 shared J.-H. Seo· 2 shared M. Ludwig· 2 shared A. Ali· 1 shared A. Almeda· 1 shared A. Day· 1 shared A. Iniguez· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

H. E. Bergom

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Author profile →

5 papers

Recent·Most cited

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

V. Rendo, M. Schubert, N. Khuu, M. F. Suarez Peredo Rodriguez, K. Huang, M. Swift, Y. He, J. Zerbib, R. Smith, J. Raaijmakers, P. Bandopadhayay, L. M. Guenther, J. H. Hwang, A. Iniguez, S. Moody, , F. Foijer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

bioRxiv · Dec 16, 2023 · PreprintCancer Biology

A spatially mapped gene expression signature for intestinal stem-like cells identifies high-risk precursors of gastric cancer

R. J. Huang, I. A. Wichmann, A. Su, A. Sathe, M. V. Shum, S. M. Grimes, R. Meka, A. Almeda, X. Bai, J. Shen, Q. Nguyen, M. R. Amieva, J. H. Hwang, H. Ji

The paper identifies a 26-gene expression signature in high-risk gastric intestinal metaplasia (GIM) that localizes to intestinal stem-like cells and is associated with increased gastric cancer risk.

bioRxiv · Sep 20, 2023Cancer Biology

Unraveling the Global Proteome and Phosphoproteome of Prostate Cancer Patient-Derived Xenografts

Z. E. Sychev, A. Day, H. E. Bergom, G. Larson, A. Ali, M. Ludwig, E. Boytim, C. Ilsa, E. Corey, S. R. Plymate, P. S. Nelson, J. H. Hwang, J. M. Drake

The paper characterizes the proteome and phosphoproteome of prostate cancer patient-derived xenografts to identify differences between neuroendocrine-like and adenocarcinoma subtypes.

bioRxiv · Aug 2, 2023Cancer Biology

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies

J. H. Hwang, R. Arafeh, J.-H. Seo, S. C. Baca, M. Ludwig, T. E. Arnoff, C. Richter, H. E. Bergom, S. McSweeney, J. P. Rennhack, S. A. Klingenberg, A. T. Cheung, J. Kwon, J. So, S. Kregel, , W. Hahn

This study identifies CREB5 as a key driver of resistance to androgen receptor targeting therapies by reprogramming nuclear interactions and activating TGFβ and Wnt signaling pathways.

bioRxiv · Aug 18, 2021Cancer Biology

Metaplasia of respiratory and digestive tissues in the Eastern oyster Crassostrea virginica associated with the Deepwater Horizon oil spill

D. Roopnarine, P. Roopnarine, L. Anderson, J. H. Hwang, S. Patel

The paper documents metaplasia in wild eastern oysters from the Gulf of Mexico post-Deepwater Horizon oil spill, showing higher rates than Chesapeake Bay controls.

bioRxiv · Feb 15, 2021Zoology