Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation
D. Heintzman, J. H. Elasy, C. Chi, X. Ye, E. Krystoviak, W. Khan, L. M. Olson, A. Jones, K. Voss, A. Patterson, A. Sugiura, F. M. Mason, H. Hong, L. E. Bass, K. L. Beier, , J. Rathmell
The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.
bioRxiv · Nov 14, 2022 · PreprintImmunology