Author

K. L. Beier

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Organism:mouse· 1

Frequent Co-Authors

A. Sugiura· 2 shared J. Rathmell· 2 shared K. Voss· 2 shared X. Ye· 2 shared A. G. Bick· 1 shared A. Jones· 1 shared A. K. Mangalam· 1 shared A. M. Cameron· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

A. Sugiura

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Author profile →

2 papers

Recent·Most cited

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

D. Heintzman, J. H. Elasy, C. Chi, X. Ye, E. Krystoviak, W. Khan, L. M. Olson, A. Jones, K. Voss, A. Patterson, A. Sugiura, F. M. Mason, H. Hong, L. E. Bass, K. L. Beier, , J. Rathmell

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

bioRxiv · Nov 14, 2022 · PreprintImmunology

MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

A. Sugiura, G. Andrejeva, K. Voss, D. R. Heintzman, K. L. Beier, M. M. Wolf, D. L. Greenwood, X. Ye, S. K. Shahi, S. N. Freedman, A. M. Cameron, P. Foerch, T. Bourne, X. Xu, J. C. Garcia-Canaveras, , J. Rathmell

This study identifies MTHFD2 as a metabolic checkpoint that regulates T cell fate and function by promoting effector cells and suppressing regulatory T cells.

bioRxiv · Feb 3, 2021Immunology