K. Voss

Mitochondrial Fatty Acid Synthesis and Mecr Regulate CD4+ T Cell Function and Oxidative Metabolism

This study shows that Mecr, a mitochondrial fatty acid synthesis gene, is critical for CD4+ T cell metabolism, function, and survival, with implications for inflammatory diseases and mitochondrial disorders.

Disruption of myelin structure and oligodendrocyte maturation in a pigtail macaque model of congenital Zika infection

This study investigates the effects of prenatal Zika virus exposure on fetal myelin structure and oligodendrocyte maturation in pigtail macaques, finding disruptions in myelin formation and gene expression related to oligodendrocyte development.

Androgen Signaling Restricts Glutaminolysis to Drive Sex-Specific Th17 Metabolism

The paper shows that androgen signaling reduces glutaminolysis in male Th17 cells, leading to sex-specific metabolic differences that affect Th17-mediated inflammation.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus

This study shows that dysregulated CD71 in T cells increases iron uptake, disrupts mitochondrial function, and drives inflammation in SLE, with CD71 blockade improving outcomes.

Single-Cell Profiling of the Antigen-Specific Response to BNT162b2 SARS-CoV-2 RNA Vaccine

MTHFD2 is a Metabolic Checkpoint Controlling Effector and Regulatory T Cell Fate and Function

This study identifies MTHFD2 as a metabolic checkpoint that regulates T cell fate and function by promoting effector cells and suppressing regulatory T cells.