F. M. Mason

Lysine Demethylase 4A is a Centrosome Associated Protein Required for Centrosome Integrity and Genomic Stability

This study identifies KDM4A as a centrosome-associated protein whose demethylase activity maintains centrosome integrity and genomic stability.

Drug screening in human physiologic medium identifies uric acid as an inhibitor of rigosertib efficacy

The paper screens drugs in human physiologic medium and identifies uric acid as an inhibitor of rigosertib's efficacy.

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

Molecular determinants for α-tubulin methylation by SETD2

This study identifies the molecular mechanisms by which SETD2 methylates α-tubulin, revealing distinct substrate recognition and catalytic requirements for tubulin versus histone methylation.

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

SETD2 is an actin lysine methyltransferase

This study identifies SETD2 as an actin lysine methyltransferase that regulates actin polymerization and cell migration through methylation of the actin cytoskeleton.