tRNA anticodon cleavage by target-activated CRISPR-Cas13a effector
I. Jain, M. Kolesnik, L. Minakhin, N. Morozova, A. Shiriaeva, A. Kirillov, S. Medvedeva, K. Kuznedelov, S. Borukhov, K. S. Makarova, E. V. Koonin, K. Severinov, E. Semenova
The paper shows that Cas13a cleaves tRNA anticodons to induce bacterial dormancy and activates toxin-antitoxin modules for mRNA and rRNA cleavage.
bioRxiv · Nov 10, 2021Microbiology