Author

A. Shiriaeva

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:cryo-EM· 2 Research Focus:protein structure prediction· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

M. W. Martynowycz· 3 shared T. Gonen· 3 shared J. Hattne· 2 shared V. Cherezov· 2 shared W. J. Nicolas· 2 shared A. Kirillov· 1 shared B. L. Nannenga· 1 shared E. Semenova· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

M. W. Martynowycz

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Author profile →

4 papers

Recent·Most cited

MicroED structure of the human vasopressin 1B receptor

A. Shiriaeva, M. W. Martynowycz, W. J. Nicolas, V. Cherezov, T. Gonen

This paper determines the structure of the human vasopressin 1B receptor using MicroED, overcoming challenges in GPCR structural determination.

bioRxiv · Jul 5, 2023 · PreprintBiochemistry

A robust approach for MicroED sample preparation of lipidic cubic phase embedded membrane protein crystals

M. W. Martynowycz, A. Shiriaeva, M. T. B. Clabbers, W. J. Nicolas, S. J. Weaver, J. Hattne, T. Gonen

This paper introduces a method to prepare lipidic cubic phase (LCP) membrane protein crystals for MicroED by using fluorescence microscopy to identify and mill crystals without converting LCP to sponge phase.

bioRxiv · Jul 26, 2022Biochemistry

tRNA anticodon cleavage by target-activated CRISPR-Cas13a effector

I. Jain, M. Kolesnik, L. Minakhin, N. Morozova, A. Shiriaeva, A. Kirillov, S. Medvedeva, K. Kuznedelov, S. Borukhov, K. S. Makarova, E. V. Koonin, K. Severinov, E. Semenova

The paper shows that Cas13a cleaves tRNA anticodons to induce bacterial dormancy and activates toxin-antitoxin modules for mRNA and rRNA cleavage.

bioRxiv · Nov 10, 2021Microbiology

MicroED structure of the human adenosine receptor determined from a single nanocrystal in LCP

M. W. Martynowycz, A. Shiriaeva, X. Ge, J. Hattne, B. L. Nannenga, V. Cherezov, T. Gonen

The paper determines the structure of the human A2A adenosine receptor using MicroED after converting LCP to sponge phase and cryoFIB milling, achieving 2.8 Å resolution.

bioRxiv · Sep 27, 2020Biophysics