Author

L. Ngai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Mortha· 4 shared K. Burrows· 4 shared P. Chiaranunt· 4 shared E. Y. Cao· 3 shared S. L. Tai· 2 shared A. Momen· 1 shared A. Nguyen· 1 shared A. Popovic· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

A. Mortha

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Author profile →

4 papers

Recent·Most cited

The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA.

E. Y. Cao, K. Burrows, P. Chiaranunt, A. Popovic, X. Zhou, C. Xie, A. Thakur, G. J. Britton, M. P. Spindler, L. Ngai, S. L. Tai, D. C. Dasoveanu, A. Nguyen, J. J. Faith, J. Parkinson, , A. Mortha

This study shows that the protozoan commensal Tritrichomonas musculis promotes T-cell dependent IgA class-switch recombination and enhances IgA-secreting plasma cell accumulation and dissemination.

bioRxiv · Oct 8, 2022Immunology

A gut commensal protozoa remotely shapes a lung niche for asthma-promoting eosinophils.

K. Burrows, L. Ngai, P. Chiaranunt, E. Cao, C. Streutker, B. Forde, L. O'Mahony, A. Mortha

This study shows that the gut protozoa Tritrichomonas musculis exacerbates asthma by promoting lung eosinophilia through a tripartite immune network.

bioRxiv · Mar 25, 2022 · PreprintImmunology

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs

P. Chiaranunt, K. Burrows, L. Ngai, E. Y. Cao, S. L. Tai, H. Hamidzada, A. Wong, M. Kuypers, T. Despot, A. Momen, S. M. Lim, T. Mallevaey, T. Conway, H. Imamura, S. Epelman, A. Mortha

The paper identifies a microbial energy metabolism-driven niche in tertiary lymphoid organs that supports intestinal macrophage development via CSF2 and ILC3 activity.

bioRxiv · Mar 23, 2022 · PreprintImmunology

NLRP1B and NLRP3 control the host response following colonization by the commensal protist Tritrichomonas musculis.

P. Chiaranunt, K. Burrows, L. Ngai, E. Y. Cao, H. Liang, C. J. Streuker, S. Girardin, A. Mortha

This study shows that NLRP1B and NLRP3 inflammasomes are required for the host immune response to the commensal protist Tritrichomonas musculis, which protects against Salmonella infections.

bioRxiv · Aug 14, 2021Immunology