Author

M. P. Spindler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Assay:proteomics· 3 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

G. J. Britton· 4 shared J. J. Faith· 4 shared I. Mogno· 2 shared A. Baltus· 1 shared A. Das· 1 shared A. Grinspan· 1 shared A. Mortha· 1 shared A. Nguyen· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersImmunology

G. J. Britton

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4 papers

Recent·Most cited

The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA.

E. Y. Cao, K. Burrows, P. Chiaranunt, A. Popovic, X. Zhou, C. Xie, A. Thakur, G. J. Britton, M. P. Spindler, L. Ngai, S. L. Tai, D. C. Dasoveanu, A. Nguyen, J. J. Faith, J. Parkinson, , A. Mortha

This study shows that the protozoan commensal Tritrichomonas musculis promotes T-cell dependent IgA class-switch recombination and enhances IgA-secreting plasma cell accumulation and dissemination.

bioRxiv · Oct 8, 2022Immunology

Species-specific CD4+ T cells Enable Prediction of Mucosal Immune Phenotypes from Microbiota Composition

M. P. Spindler, I. Mogno, P. Suri, G. J. Britton, J. J. Faith

The paper identifies bacterial strains that drive specific mucosal T cell phenotypes using gnotobiotic mice and ex vivo assays, showing strain-specific T cell responses.

bioRxiv · Aug 13, 2022 · PreprintImmunology

Defining Innate Immune Responses to the Human Gut Microbiota from Phylum to Strain

M. P. Spindler, S. S. Siu, I. Mogno, Z. Li, C. Yang, S. Mehandru, G. J. Britton, J. J. Faith

This study screens 277 gut bacterial strains to define innate immune responses, showing strain-specific and phylum-level variations in immune activation.

bioRxiv · Nov 13, 2021 · PreprintImmunology

Defined microbiota transplant restores Th17/RORtγ+ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas

G. J. Britton, E. J. Contijoch, M. P. Spindler, V. Aggarwala, G. Bongers, L. San Mateo, A. Baltus, A. Das, D. Gevers, T. J. Borody, N. O. Kaakoush, M. A. Kamm, H. Mitchell, S. Paramsothy, J. C. Clemente, , J. J. Faith

The paper shows that transplanting healthy microbiota into mice with IBD microbiotas restores Th17/RORγt+ regulatory T cell balance by reducing pathogenic strains.

bioRxiv · Nov 16, 2019Immunology