J. Parkinson

The commensal protist Tritrichomonas musculus exhibits a dynamic life cycle that induces extensive remodeling of the gut microbiota

This study examines the impact of the commensal protist Tritrichomonas musculus on gut microbiota dynamics in mice, revealing protist-driven microbiome remodeling and distinct life stages of the protist.

IL-17A promotes epithelial cell IL-33 production during nematode lung migration

This study shows IL-17A promotes IL-33 production in lung epithelial cells during nematode infection, independent of IFN-gamma suppression.

The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA.

This study shows that the protozoan commensal Tritrichomonas musculis promotes T-cell dependent IgA class-switch recombination and enhances IgA-secreting plasma cell accumulation and dissemination.

The faecal metabolome and its determinants in inflammatory bowel disease

This study identifies metabolic alterations in IBD patients by analyzing faecal metabolites, metagenomics, host genetics, and clinical data, finding over 300 differentially abundant molecules and associations with microbiota and diet.

Genotype and Th2 cells control monocyte to tissue resident macrophage differentiation during nematode infection of the pleural cavity

This study shows that host genetics and Th2 cells influence monocyte-to-tissue-resident-macrophage differentiation during nematode infection in mice.

Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism

This study shows diurnal rhythms in intestinal IgA regulate oscillations in commensal microbiota abundance, promoting mutualism.

ToxoNet: A high confidence map of protein-protein interactions in Toxoplasma gondii reveals novel virulence factors implicated in host cell invasion

ToxoNet constructs a high-confidence protein-protein interaction map for Toxoplasma gondii, identifying novel virulence factors involved in host cell invasion.

Toxoplasma infection alters dopamine-sensitive behaviors and host gene expression patterns associated with neuropsychiatric disease

This study investigates how Toxoplasma gondii infection affects dopamine-sensitive behaviors and gene expression in mice, revealing interactions between infection and cocaine exposure that may contribute to neuropsychiatric disorders.

Micronutrient supplements with iron promote disruptive protozoan and fungal communities in the developing infant gut

This study examines how micronutrient supplements, particularly iron, affect protozoan and fungal communities in infants' guts, showing both risks and benefits depending on environmental factors.

IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection

This study shows that IL-13 reduces lung damage and supports epithelial type 2 molecule production during nematode infection in mice.

Discovery and characterization of a Gram-positive Pel polysaccharide biosynthetic gene cluster

The paper identifies and characterizes a Pel polysaccharide biosynthetic gene cluster in Gram-positive bacteria, showing its role in biofilm formation and regulation by c-di-GMP.

Inflammasome-independent role for NLRP3 in controlling innate anti-helminth immunity and tissue repair in the lung

This study shows NLRP3 limits lung neutrophilia and helminth killing in an inflammasome-independent way, while promoting tissue repair.