A. Mortha

Single-cell transcriptomics reveals colonic immune perturbations during amyloid-β driven Alzheimer's disease in mice

This study uses single-cell RNA sequencing to identify immune changes in the colon of Alzheimer's disease mice, finding reduced antibody-secreting cells and altered immune trafficking.

Cell therapy with IL-10-producing group 2 innate lymphoid cells suppresses Graft-versus-Host disease

This study demonstrates that IL-10-producing group 2 innate lymphoid cells (ILC210) can suppress Graft-versus-Host Disease (GVHD) in a humanized model without compromising graft-versus-leukemic effects.

The commensal protist Tritrichomonas musculus exhibits a dynamic life cycle that induces extensive remodeling of the gut microbiota

This study examines the impact of the commensal protist Tritrichomonas musculus on gut microbiota dynamics in mice, revealing protist-driven microbiome remodeling and distinct life stages of the protist.

The protozoan commensal Tritrichomonas musculis is a natural adjuvant for mucosal IgA.

This study shows that the protozoan commensal Tritrichomonas musculis promotes T-cell dependent IgA class-switch recombination and enhances IgA-secreting plasma cell accumulation and dissemination.

A gut commensal protozoa remotely shapes a lung niche for asthma-promoting eosinophils.

This study shows that the gut protozoa Tritrichomonas musculis exacerbates asthma by promoting lung eosinophilia through a tripartite immune network.

Microbial Energy Metabolism Fuels a CSF2-dependent Intestinal Macrophage Niche within Tertiary Lymphoid Organs

The paper identifies a microbial energy metabolism-driven niche in tertiary lymphoid organs that supports intestinal macrophage development via CSF2 and ILC3 activity.

NLRP1B and NLRP3 control the host response following colonization by the commensal protist Tritrichomonas musculis.

This study shows that NLRP1B and NLRP3 inflammasomes are required for the host immune response to the commensal protist Tritrichomonas musculis, which protects against Salmonella infections.

Deciphering the combinatorial influence of diet and the microbiota on experimental colitis

This study investigates how diet and microbiota interact to influence colitis severity in mice, finding that protein and psyllium fiber have significant effects through microbiota-dependent and independent mechanisms.