Author

L. Pearl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Organism:human· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

A. Oliver· 1 shared D. Boos· 1 shared E. A. Outwin· 1 shared J. Oberoi· 1 shared J. S. Chaudhary· 1 shared K. Ptasinska· 1 shared M. Day· 1 shared M. Rappas· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiochemistry

A. Oliver

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation

L. Pearl, J. Oberoi, X. Aran-Guiu, E. A. Outwin, P. Schellenberger, T. I. Roumeliotis, J. S. Chaudhary

The paper presents cryoEM structures of HSP90-CDC37-BRAFV600E complexes with PP5, showing how PP5 dephosphorylates client kinases upon recruitment to HSP90 complexes.

bioRxiv · May 3, 2022Biochemistry

N-terminal BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

M. Day, M. Rappas, K. Ptasinska, D. Boos, A. Oliver, L. Pearl

The paper defines the specificity of N-terminal BRCT domains in TOPBP1/Rad4 for phosphopeptide ligands through structural and biochemical analysis of their interactions with various proteins.

bioRxiv · Jul 13, 2018Biochemistry