Author

M. Rappas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Dermenci· 1 shared A. Flick· 1 shared A. Oliver· 1 shared A. Round· 1 shared A. Thorarensen· 1 shared A. Wrona· 1 shared B. J. Hogan· 1 shared B. S. Gerstenberger· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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1 shared paperBiochemistry

A. Dermenci

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural basis for CCR6 modulation by allosteric antagonists

D. J. Wasilko, B. S. Gerstenberger, K. A. Farley, W. Li, J. Alley, M. E. Schnute, R. J. Unwalla, J. Victorino, K. K. Crouse, R. Ding, P. V. Sahasrabudhe, F. Vincent, R. K. Frisbie, A. Dermenci, A. Flick, , H. Wu

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

bioRxiv · Apr 5, 2024Biochemistry

Mix-and-extrude: high-viscosity sample injection towards time-resolved protein crystallography

M. Vakili, H. Han, C. Schmidt, A. Wrona, M. Kloos, I. de Diego, K. Dorner, T. Geng, C. Kim, F. Koua, D. Melo, M. Rappas, A. Round, E. Round, M. Sikorski, , J. Schulz

This paper introduces a mix-and-extrude method for time-resolved protein crystallography using 3D printed microchannels to study ligand-induced reactions in viscous media.

bioRxiv · Nov 23, 2022Biochemistry

N-terminal BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands

M. Day, M. Rappas, K. Ptasinska, D. Boos, A. Oliver, L. Pearl

The paper defines the specificity of N-terminal BRCT domains in TOPBP1/Rad4 for phosphopeptide ligands through structural and biochemical analysis of their interactions with various proteins.

bioRxiv · Jul 13, 2018Biochemistry