Author

X. Aran-Guiu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Organism:yeast· 1

Frequent Co-Authors

A. Acharya· 1 shared A. Sanchez· 1 shared C. Adam· 1 shared E. A. Outwin· 1 shared E. Cannavo· 1 shared E. R. Hoffman· 1 shared J. Hugener· 1 shared J. Matos· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

A. Acharya

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2 papers

Recent·Most cited

HSP90-CDC37-PP5 forms a structural platform for kinase dephosphorylation

L. Pearl, J. Oberoi, X. Aran-Guiu, E. A. Outwin, P. Schellenberger, T. I. Roumeliotis, J. S. Chaudhary

The paper presents cryoEM structures of HSP90-CDC37-BRAFV600E complexes with PP5, showing how PP5 dephosphorylates client kinases upon recruitment to HSP90 complexes.

bioRxiv · May 3, 2022Biochemistry

Regulation of the MLH1-MLH3 endonuclease in meiosis

E. Cannavo, A. Sanchez, R. Anand, L. Ranjha, J. Hugener, C. Adam, A. Acharya, N. Weyland, X. Aran-Guiu, J.-B. Charbonnier, E. R. Hoffman, V. Borde, J. Matos, P. Cejka

This paper identifies the molecular mechanism by which the MLH1-MLH3 nuclease is activated in meiosis, showing its interaction with MutSγ, EXO1, RFC, and PCNA to process recombination intermediates.

bioRxiv · Feb 12, 2020Biochemistry