Author

L. Prendergast

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Safina· 1 shared B. Weston· 1 shared D. Rico· 1 shared E. C. Gomez· 1 shared E. Willmore· 1 shared H. L. Smith· 1 shared I. Goswami· 1 shared J. L. Mitchell· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

A. Safina

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Overcoming PARP inhibitor resistance by inducing a homologous recombination repair defective phenotype with ATR, CHK1 and WEE1 inhibitors

H. L. Smith, E. Willmore, L. Prendergast, N. J. Curtin

This paper shows that ATR, CHK1, and WEE1 inhibitors induce an HRD phenotype, making cells sensitive to PARP inhibitors.

bioRxiv · Jul 5, 2023 · PreprintCancer Biology

Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation

R. J. Harris, M. Heer, M. D. Levasseur, T. N. Cartwright, B. Weston, J. L. Mitchell, J. M. Coxhead, L. Gaughan, L. Prendergast, D. Rico, J. M. G. Higgins

The paper investigates the interaction between H3K4me3 and H3T3ph during mitosis, finding that H3T3ph does not prevent H3K4 reader binding, challenging the histone code hypothesis in this context.

bioRxiv · Feb 28, 2023Cell Biology

Prevention of chromatin destabilization by FACT is crucial for malignant transformation

P. Sandlesh, A. Safina, I. Goswami, L. Prendergast, S. Rosario, E. C. Gomez, J. Wanf, K. V. Gurova

The paper shows that FACT prevents chromatin destabilization in transformed cells, which is crucial for malignant transformation and survival.

bioRxiv · Dec 17, 2018Cell Biology