H. L. Smith

Overcoming PARP inhibitor resistance by inducing a homologous recombination repair defective phenotype with ATR, CHK1 and WEE1 inhibitors

This paper shows that ATR, CHK1, and WEE1 inhibitors induce an HRD phenotype, making cells sensitive to PARP inhibitors.

PERK-ATAD3A interaction protects mitochondrial proteins synthesis during ER stress

The paper identifies ATAD3A as a PERK interactor that modulates PERK-eIF2 signaling during ER stress, allowing selective translation of mitochondrial proteins.

Differences in durability of PARP inhibition by clinically approved PARP inhibitors: implications for combinations and scheduling

This paper compares the durability of PARP inhibition by five PARP inhibitors in ovarian cancer cells and shows rucaparib provides the longest-lasting inhibition, with implications for combination therapies with ATR inhibitors.

Domain Binding and Isotype Dictate the Activity of Anti-human OX40 Antibodies

This study evaluates how isotype and epitope of anti-human OX40 antibodies affect their therapeutic activity in tumor models.

The rapid regenerative response of a model sea anemone species Exaiptasia pallida is characterised by tissue plasticity and highly coordinated cell communication

This study identifies key genes and pathways involved in the rapid regeneration of Exaiptasia pallida, highlighting tissue plasticity and coordinated cell communication.