Author

L. Reinert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

C. K. Holm· 2 shared D. Olagnier· 2 shared J. Thyrsted· 2 shared M. Idorn· 2 shared S. R. Paludan· 2 shared A. Alcami· 1 shared A. G. Oliver· 1 shared A. Hait· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

C. K. Holm

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brain

S. Fruhwurth, L. Reinert, C. Oberg, M. Sakr, M. Henricsson, H. Zetterberg, S. Paludan

This study shows that TREM2 is critical for microglial antiviral responses against HSV1, enhancing IFN-I production and phagocytosis, and its loss increases susceptibility to infection.

bioRxiv · Mar 16, 2023 · PreprintImmunology

Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19

R. M. van der Sluis, L. B. Cham, A. G. Oliver, K. R. Gammelgaard, J. G. Pedersen, M. Idorn, U. Ahmodov, S. S. Hernandez, E. Cemalovic, S. H. Godsk, J. Thyrsted, J. D. Gunst, S. D. Nielsen, J. j. Jorgensen, T. W. Bjerg, , M. R. Jakobsen

The paper shows that pDCs use TLR7 for antiviral responses and TLR2 for inflammatory responses to SARS-CoV-2, with neuropilin-1 inhibiting antiviral IFNs.

bioRxiv · Nov 23, 2021 · PreprintImmunology

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

D. Olagnier, E. Farahani, J. Thyrsted, J. B. Cadanet, A. Herengt, M. Idorn, A. Hait, B. Hernaez, A. Knudsen, M. B. Iversen, M. Schilling, S. E. Jorgensen, M. Thomsen, L. Reinert, M. Lappe, , C. K. Holm

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

bioRxiv · Jul 16, 2020Microbiology