S. R. Paludan

STING activation counters glioblastoma by vascular alteration and immune surveillance

This study shows that STING activation reduces glioblastoma progression and prolongs survival by altering tumor vasculature and enhancing immune surveillance.

Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

The paper identifies metabolic changes in serine metabolism linked to cGAS/STING-signalling and immune response in gut inflammation.

Distinct SARS-CoV-2 sensing pathways in pDCs driving TLR7-antiviral vs. TLR2-immunopathological responses in COVID-19

The paper shows that pDCs use TLR7 for antiviral responses and TLR2 for inflammatory responses to SARS-CoV-2, with neuropilin-1 inhibiting antiviral IFNs.

ZBP1 induces inflammatory signaling via RIPK3 and promotes SARS-CoV-2-induced cytokine expression

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

Sting orchestrates the crosstalk between polyunsaturated fatty acids metabolism and inflammatory responses

This study identifies Sting as a regulator of fatty acid metabolism and shows its cross-talk with PUFAs to modulate inflammatory responses.

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

Ionophore antibiotic X-206 is a potent and selective inhibitor of SARS-CoV-2 infection in vitro

This study identifies X-206, a polyether ionophore antibiotic, as a potent and selective inhibitor of SARS-CoV-2 infection in vitro with high selectivity and sub-nM efficacy.

Intracorneal delivery of HSV-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis

This study demonstrates that intracorneal delivery of HSV-1-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis in both animal models and human-derived corneas.

Inhibition of Sting rescues lupus disease by the regulation of Lyn-mediated dendritic cell differentiation

This study shows that inhibiting STING signaling rescues lupus disease by regulating Lyn-mediated dendritic cell differentiation.

Varicella-zoster virus CNS vasculitis and RNA polymerase III gene mutation in identical twins

The paper reports a rare POLR3F mutation in monozygotic twins with severe CNS VZV vasculitis, linking RNA polymerase III dysfunction to increased susceptibility to VZV infection.