Author

L. S. Handal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:deep learning· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1

Frequent Co-Authors

J. E. Crowe· 3 shared E. Binshtein· 2 shared J. X. Reidy· 2 shared T. B. Engdahl· 2 shared A. Bukreyev· 1 shared A. Ladd· 1 shared A. M. Lillo· 1 shared A. T. Zemla· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

J. E. Crowe

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

T. A. Desautels, K. T. Arrildt, A. T. Zemla, E. Y. Lau, F. Zhu, D. Ricci, S. Cronin, S. Zost, E. Binshtein, S. M. Scheaffer, B. Dadonaite, B. K. Petersen, T. B. Engdahl, E. Chen, L. S. Handal, , Carnahan

This paper computationally redesigns an antibody to restore potency against SARS-CoV-2 Omicron subvariants while maintaining efficacy against Delta and other variants.

Nature · May 8, 2024Peer-reviewedMicrobiology

Potently neutralizing human monoclonal antibodies against the zoonotic pararubulavirus Sosuga virus

H. M. Parrington, N. Kose, E. Armstrong, L. S. Handal, S. Diaz, J. X. Reidy, J. Dong, G. B. E. Stewart-Jones, P. Shrivastava-Ranjan, S. Jain, C. G. Albarino, R. H. Carnahan, J. E. Crowe

The paper identifies potent human monoclonal antibodies against Sosuga virus, revealing epitope diversity and neutralization mechanisms.

bioRxiv · Nov 17, 2022Immunology

Antigenic mapping and functional characterization of human New World hantavirus neutralizing antibodies

T. B. Engdahl, E. Binshtein, R. L. Brocato, N. A. A. Kuzmina, L. M. Principe, S. A. Kwilas, R. K. Kim, N. S. Chapman, M. S. Porter, P. Guardado-Calvo, F. A. Rey, L. S. Handal, S. M. Diaz, I. A. Zagol-Ikapitte, J. X. Reidy, , J. E. Crowe

This study maps antigenic sites and characterizes neutralizing antibodies against hantaviruses, identifying mechanisms and cross-protective potential for vaccine development.

bioRxiv · Jul 19, 2022Immunology