Author

C. C. Ward

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 5 Approach:experimental assay· 5 Organism:human· 5 Assay:proteomics· 4 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

D. K. Nomura· 4 shared J. M. McKenna· 4 shared J. N. Spradlin· 4 shared M. Schirle· 4 shared D. Dovala· 3 shared J. A. Tallarico· 3 shared S. M. Brittain· 3 shared J. R. Thomas· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersBiochemistry

D. K. Nomura

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Discovery of Potent Pyrazoline-Based Covalent SARS-CoV-2 Main Protease Inhibitors

P. Moon, L. Boike, D. Dovala, N. J. Henning, M. Knapp, J. N. Spradlin, C. C. Ward, H. Wolleb, C. M. Zammit, D. Fuller, G. Blake, J. P. Murphy, F. Wang, Y. Lu, S. A. Moquin, , D. K. Nomura

This study identifies and optimizes potent pyrazoline-based covalent inhibitors of SARS-CoV-2 Mpro, showing activity against multiple coronaviruses.

bioRxiv · Mar 5, 2022Biochemistry

ChAdOx1 nCoV-19 (AZD1222) vaccine elicits monoclonal antibodies with potent cross-neutralizing activity against SARS-CoV-2 viral variants

J. Seow, C. Graham, S. R. Hallett, T. Lechmere, T. J. A. Maguire, I. Huettner, D. Cox, R. Roberts, A. Waters, C. C. Ward, C. Mant, M. J. Pitcher, J. Spencer, J. Fox, M. H. Malim, K. J. Doores

This study isolates monoclonal antibodies from a vaccinated individual and shows they neutralize multiple SARS-CoV-2 variants effectively.

bioRxiv · Sep 27, 2021Immunology

Deubiquitinase-Targeting Chimeras for Targeted Protein Stabilization

N. J. Henning, L. Boike, J. N. Spradlin, C. C. Ward, B. Belcher, S. M. Brittain, M. Hesse, D. Dovala, L. M. McGregor, J. M. McKenna, J. A. Tallarico, M. Schirle, D. K. Nomura

This paper introduces the DUBTAC platform for targeted protein stabilization by linking a covalent OTUB1 recruiter to lumacaftor, demonstrating stabilization of ΔF508-CFTR in human cells.

bioRxiv · Apr 30, 2021Biochemistry

Screening a library of FDA-approved and bioactive compounds for antiviral activity against SARS-CoV-2

S. B. Biering, E. Van Dis, E. Wehri, L. H. Yamashiro, X. Nguyenla, C. Dugast-Darzacq, T. G. Graham, J. R. Stroumza, G. R. Golovkine, A. W. Roberts, D. M. Fines, J. N. Spradlin, C. C. Ward, T. Bajaj, D. Dovala, , S. A. Stanley

This study screens FDA-approved compounds for antiviral activity against SARS-CoV-2 and identifies 13 effective compounds, including seven new candidates and one synergistic combination with remdesivir.

bioRxiv · Dec 30, 2020Microbiology

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

J. N. Spradlin, X. Hu, C. C. Ward, S. M. Brittain, M. D. Jones, L. Ou, M. To, A. Proudfoot, E. Ornleas, M. Woldegiorgis, J. A. Olzmann, D. E. Bussiere, J. R. Thomas, J. A. Tallarico, J. M. McKenna, , D. K. Nomura

This study identifies nimbolide's mechanism of action by showing it targets RNF114, leading to stabilization of p21 and inhibition of breast cancer cell proliferation.

bioRxiv · Apr 9, 2019Cancer Biology

Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications

C. C. Ward, J. I. Kleinman, S. M. Brittain, P. S. Lee, C. Y. S. Chung, K. Kim, Y. Petri, J. R. Thomas, J. A. Tallarico, J. M. McKenna, M. Schirle, D. K. Nomura

This study identifies a covalent ligand for RNF4, an E3 ligase, and demonstrates its use in designing a bifunctional degrader that effectively degrades BRD4.

bioRxiv · Nov 16, 2018Biochemistry