BiochemistrybioRxiv
The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA double strand repair through mutual regulation of their protein levels
D. Mennerich, Y. Ashok, C. Vela-Rodriguez…·T. Kietzmann
This paper identifies a regulatory feedback loop between DTX3L and USP28 that modulates DNA double-strand break repair by controlling protein levels and repair pathway efficiency.
DOI 10.1016/j.isci.2025.112990