Author

K. D. Wittrup

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:CITE-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. J. Irvine· 3 shared J. A. Stinson· 3 shared L. Santollani· 3 shared A. Sheen· 2 shared J. R. Palmeri· 2 shared L. Maiorino· 2 shared L. R. Duhamel· 2 shared N. Momin· 2 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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3 shared papersImmunology

D. J. Irvine

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tumor-localized interleukin-2 and interleukin-12 combine with radiation therapy to safely potentiate regression of advanced malignant melanoma in pet dogs

J. A. Stinson, M. M. P. Barbosa, A. Sheen, N. Momin, E. Fink, J. Hampel, K. Selting, R. Kamerer, K. L. Bailey, K. D. Wittrup, T. M. Fan

This study evaluates collagen-binding IL-2 and IL-12 in pet dogs with melanoma, showing local and regional therapeutic responses that suggest potential human clinical benefit.

bioRxiv · Feb 12, 2024Cancer Biology

Local delivery of cell surface-targeted immunocytokines programs systemic anti-tumor immunity

L. Santollani, Y. J. Zhang, L. Maiorino, J. R. Palmeri, J. A. Stinson, L. R. Duhamel, K. Qureshi, J. R. Suggs, O. T. Porth, W. Pinney, R. Al Msari, K. D. Wittrup, D. J. Irvine

This study develops CD45-targeted immunocytokines that localize to immune cells in tumors and lymph nodes, eradicating both treated and distant tumors in mouse models.

bioRxiv · Jan 3, 2024 · PreprintImmunology

Tregs constrain CD8+ T cell priming required for curative intratumorally anchored anti-4-1BB immunotherapy

J. R. Palmeri, B. M. Lax, J. M. Peters, L. R. Duhamel, J. A. Stinson, L. Santollani, E. A. Lutz, W. Pinney, B. D. Bryson, K. D. Wittrup

The paper shows that inhibiting Tregs enhances CD8+ T cell priming, improving antitumor responses to 4-1BB combination therapy.

bioRxiv · Jan 30, 2023 · PreprintImmunology

Reprogramming brain immunosurveillance with engineered cytokines

A. Tabet, Y. Agarwal, J. Stinson, C. Apra, V. Will, M. Manthey, N. Momin, A. Sheen, M. Murdock, L. Santollani, L.-H. Tsai, I. Chiu, S. E. Lawler, D. J. Irvine, K. D. Wittrup, P. Anikeeva

This study shows engineered cytokines can reprogram brain immunosurveillance by extending their residence time in the brain using alum scaffolds, delaying tumor progression in mouse models.

bioRxiv · Jun 21, 2022 · PreprintBioengineering

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma

B. E. Grace, C. M. Backlund, D. M. Morgan, B. H. Kang, N. K. Singh, B. D. Huisman, C. G. Rappazzo, K. D. Moynihan, L. Maiorino, C. S. Dobson, T. Kyung, K. S. Gordon, P. V. Holec, O. C. T. Mbah, D. Garafola, , M. E. Birnbaum

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

bioRxiv · Feb 28, 2022Immunology